FDA

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Primary care doctors as well as psychiatrists give out antidepressants more than other kinds of medicine.

At the time I started training in psychiatry, we memorized the antidepressant side effects for early chemical classes derived from antituberculosis drugs and became overjoyed when the SSRIs came out.  Actually something safe and effective and pretty “clean” of risks and side effects and interactions!  First Prozac, which was FDA approved a day I was getting off call and grabbing a few hours of shuteye to be awakened by the morning news proclaiming that the new “safe” antidepressant would be a “wonderful advancement for psychiatry.” Read more on …

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I remember my respected psychopharmacology preceptor always had a pile of a bit out of date copies of the Wall Street Journal sitting around the house.  I asked him why — about the third time I saw them sitting around his living room. He explained to me then it was the thing you really had to read to know what was going on in the pharmaceutical industry.

I remember I rolled my eyes heaven ward.  I was too busy memorizing molecular structures and trying to understand potential mechanisms of drug-drug interactions. I still do a bunch of that sort of thing.  I do it more quickly than I did at that time, but I still do it.  Oh, I will find on line pretty much anything I can in “Newsfeeds” and such, but it is more to condemn than to follow these days, from what I know and can see. Basically, my problem is that they seem to keep making better sounding drugs.  But from what I read, I don’t usually see them as a clear CLINICAL improvement over what I have seen in the past. In other words, I don’t think they are making people “more better” in terms of having more efficacy or less side effects or such.  I just can’t find it in statistics in general, and sometimes even wonder if statistics are not a tad “Gerrymandered.”

Read more on How They Plan To Sell Even More Drugs Next…

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Okay, those lovable folks at Purdue Pharmaceutical decided to claim that Oxycontin, one of the favorite drugs at least of the street addicts I have seen and treated at an addiction center, is less “addictive” and less “abusable” than similar drugs.

Read more on Can’t They Sell Enough Oxycontin?…

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I have been friendly with and received referrals from homeopaths. and taken care of patients who have sung the praises of that art.  Since I am known to most folks as an “alternative physician,” this is understandable.  All homeopaths have been gentle folks, and I supposed that they were doing people good, in some way, be it placebo or something else.  I had no reason to fight them. I cannot remember ever actually referring someone to a homeopath.  Some people have told me it did not work for them.  And even though I use alternative methods,  I do things that are scientifically proven to my satisfaction.

I have never told anyone to stop seeing a homeopath who was helpful to them.  I decide on the basis of safety and efficacy for every treatment, as best I can.  Even if I sometimes have wondered about efficacy, I will admit. But for safety, homeopathy is off the charts.  I know of no down-side. I remember looking at the “dilution” level of the remedies.  In general, they are so dilute that they could not possibly have any of the “substance” that was used to make them, not even a molecule.

Read more on The Current State of Homeopathy…

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I remember, several years ago, going to a national drug development meeting; the first time I had been at such a meeting, with drug company folks from the highest national levels. I remember how excited I was.  Maybe someone could develop an antipsychotic that really could escape all those neuromuscular side effects.  Maybe they had new things that were more powerful than antibiotics, which I already knew were not working as well as they ought to. I remember, with characteristic naivete, that it felt impossible to find anyone with whom I could discuss the pharmacology that so impassioned me, for the “big” drug guys seemed to be more interested in the business and politics of the thing. Read more on Could Fish Oil Prevent Schizophrenia?…

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Anaphylaxis is frightening — it can and does kill people. It is an acute allergic reaction that affects about 0.5  to 2% of the population, at some point in life, and the frequency seems to be rising as we speak. Symptoms include hives and itches and swelling, which about 20% of the time can affect the upper breathing system and close the windpipe.

In theory any substance that is not included as part of the body can cause it.  I have heard about it being caused by bee stings, snake bites, foods and drugs and such. I have actually treated people for post-traumatic stress disorder caused by an allergic attack.  It is a serious stress to find your windpipe closing up and not know why. The lifesaving immediate emergency treatment is injected epinephrine (adrenaline) and getting the victim to a medical center to follow up with antihistamine and steroids as needed. My own allergies have given me some weird things over the years — lots of positive skin tests.  I used to suffer through “desensitization” protocols — allergen injections that made me sick, and prize-winning hay fever attacks. Read more on The EpiPen Mess and How To Work Around It…

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I kind of like ABC news, since they at least reported the news about azithromycin and a lot of other folks didn’t.

For more information, here is the original article, and here is the FDA safety announcement (this link leads to a PDF which will load in a separate window, but you must have the Adobe Acrobat reader – free – installed). Read more on Azithromycin Scare…

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I used to really enjoy going to the kind of tiny circuses that tour the small towns in rural areas.  Much of my adult life has been as a wandering gypsy doctor through such areas and it seems that many of the little towns had little to offer and went wild when the circus came to town – no matter how modest the offerings were.

Of course I had experience with the really big shows.  When I was a kid my folks took me once to the Greatest Show On Earth — Ringling Brothers, Barnum and Bailey — where I think now the plethora of amusements in three rings is probably best suited for those who really enjoy their attention deficit disorder.
But it was in a tiny field in France by a beach on the English Channel that I saw a lovely one ring circus. I was most impressed with the lion tamer — a person of African descent, large and muscled and handsome — but I was close enough to see each time he put his head in the lion’s mouth, and he did it multiple times.

The old, indifferent lion had no teeth, but the effect was still thrilling.

The image was vivid, and I have not thought of it for many years.

I think of it when I hear talk about the Food and Drug administration (FDA).

The FDA has no teeth, and as you can tell from the interview below, is simply

Read more on FDA: A Toothless Old Lion…

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