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Topic:  Research Fraud

For someone who has been a part of many clinical trials, I will be the first to admit that I have very little training in research design or statistics.  Oh, the hours I’ve spent surreptitiously curled up on the sofa of a doctors’ lounge or my own apartment, thinking that somebody paid somebody a lot of money to write “science” so I could figure out how and why I would know things.  It pretty much worked. There were a few mentions of statistics at my delightfully thorough prep school, but there was not so much as a word at medical school.  The research types were always hanging around medical school settings — their brains rented and services bought by the medical side of things — as they did not make much money.  We did receive some wonderful instruction from clinicians as to how to evaluate research literature and decide how to apply it to our practices.

I have a vivid memory of an endearing shy and spindly instructor during a course required for incipient biologists at Boston University.  He had Jewish afro hair, coke bottle bottom glasses, and a more than passing resemblance to a young Woody Allen.  Oh, how he despaired that we were mostly going to be money-chain doctors as opposed to truth-chasing scientists. I remember that once, and only once, did he reach fiery intensity in that class. “Nothing will be published unless the probability that it actually shows what it is supposed to show is greater than 19 out of 20, that means p>.05.  But nobody wants to admit what that really means.” Oh, how silent we were, on the edge of our chairs. Read more on Research Fraud Isn’t Reported To The Public…

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Strange, that the meningitis-tainted steroids in Tennessee  make me think of the chocolate bar case from Oklahoma. Two young, and it seemed to me, perfectly honest if somewhat histrionic  young women who found worms in their Hershey bars — the hard way.  Both were unemployed and mothers of several children each, and one was pregnant.  They were enjoying their chocolate bars in a dark room by the light of the TV set when one noticed something funny. Comparing experiences, the other one agreed that the bars tasted “off.” Turning on the lights (and — pardon me — spitting out the foul tasting candy) they saw a horrible sight.  The almonds were infested with worms. Oh, it was  scary, and one in particular told me she started throwing up, and had lost weight.  She had developed some sort of a phobia for chocolate bars in general, and had poor sleep, and was 3 months pregnant.  They both had the classic signs of Post Traumatic Stress Disorder — they could not stop thinking about and reliving the ordeal, they developed an avoidance of any chocolate or other type of candy bar, and they had a violent “startle” reaction if they encountered a TV commercial or if somebody they saw in public was eating a candy bar. Now the expectant mother did not particularly want to medicate for fear of damaging her unborn child, and that was fine with me.  I recall we tried to use a little relaxation, or NLP  (neurolinguistic programming), or anything, really, non-medical to calm  down this young lady.  We succeeded, at least somewhat, but not entirely. She did tell me that the Hershey bar had  “been around” for a  little, but I was unaware of any expiry date existing for Hershey bars;  checked some at the supermarket, and never saw a date. Read more on Meningitis and Hershey Bars…

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Putting scientists in prison because they did not accurately predict the danger of an earthquake and communicate it to the people is without precedent – at least as far as I can find.  And it’s probably not a terribly good idea. I guess the lawyers will appeal this one, but there is something else going on.

Junior High geography was pretty colorful at my prep school.  We studied the world, particularly the modern world, with a teacher who held us completely spellbound.  She had used all of her summers for traveling and showered us with rich discussions of the Mediterranean.  She painted a picture of a sun-drenched Italy that I found hard to connect to the ancient stories I heard about in Latin class. Read more on Legal Punishment When Scientists Fail to Warn of Earthquake…

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The psychological ability to adjust to chronic medical illness is an area where there has been very little study.  Lately, I find myself working mostly with this population of people.  I’m noticing that some adjust very well and some do it very poorly.  It depends on a lot of factors.

The situation is clearest when the illness we’re talking about is back or neck pain.  Back pain, more than neck pain, has been clearly correlated to the presence of major depression.  If a person walks into the office crying and says they’re having trouble controlling what’s going on, it’s a pretty sure bet we’re dealing with depression.

Most back pain patients aren’t prepared for the kinds of life adjustments they are required to make.  Generally, many will need to switch from a job that has involved lifting or other physical work to a job that is more sedentary.  Quite honestly, most back pain patients are in no way prepared to do this.  Mostly, this is because anything that is sedentary is going to require a higher level of education.  Most of the folks I’m seeing are not highly educated, so the back pain leads to incapacity. Read more on Adjusting to Medical Illness…

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Do Not Go Gentle into That Good Night, that old Dylan Thomas poem, is a favorite of many mature adults, including me.

Do not go gentle into that good night
Rage, Rage against the dying of the light

Let’s face it — none of us is getting any younger.  And as we age, we’ve got to choose – will we rage, or will we just go gently.
I remember someone who alleged they wanted to work with me telling me they were interested in working with an emeritus neuroscientist.  He was a very sharp guy, at least as far as I could tell from his academic publications.  He had been with the system a long time and published much.  I had not, since I’ve never seemed to fit into that system any better than most other systems.
The project fizzled for a number of reasons, not the least of which was the news that his family was up in arms because this elderly gentleman had given the overwhelming bulk of his life savings to one of those delightful online scams.
I have not checked what the country of Nigeria is doing in terms of industry, but they seem to be leading the way when it comes to these scams.  They promise tremendous amounts of money, starting with an email to a recipient that purports to be a personal email but which surely has been delivered in bulk.  All the recipient has to do is advance a little money to get a lot.  A greed factor then takes over, and the recipient advances more and more money in hopes of a big payoff — which does not seem to happen. Anyone who has not received at least one such email is probably not a big internet user, to say the least.  I have received them in three languages, and I do almost all of my internet work in English.
It has been known for a long time that old folks are most often prey to the financially unscrupulous.  Personally, I think that the isolationism and diminished social function that often come with aging play at least as much a part in this as neuroscience does.  But for the moment, let’s assume that at least some of the problem is a loss of judgment that comes with age. Assessing individual financial capacities may be helpful — for families and guardians and stuff — but there is a delirious amount of variability here.
The typical American solution of let’s-make-more-rules may not be the way out.
At quite a young age, I saw my Grandfather-of-Blessed-Memory tell my mother that he had a daughter in Boston – even though she was standing right in front of him.  He simply could not recognize her.  As she stood there crying like a fountain, I knew I was in some kind of trouble.
Read more on No More Cognitive Loss for Age…

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Prison populations continue to rise while rehabilitation efforts, if they even exist, continue to fail.  We can do so much better.  The Washington state prison system might just be onto something really, really good. Read more on Let’s Help Prisoners Contribute to the Greater Social Good…

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The USA Today has highlighted a new study that says newlyweds who have “cold feet” going into marriage are more likely to divorce.  I say make sure those feet are warm because divorce can be hell and children can be enveloped in that hell if you wait long enough.
I found the abstract of this study, but the dry academic summary tells me very little about the actual study.  I can view a copy of the study if I pay for it, but I regard this as a low down dirty trick perpetuated by academics who want us to think their research is always worth something — which it’s not, necessarily.  Notably, I am unable to access any juicy gossip points that may actually tell me something useful, such as who paid for the study. 
This always seems to have something to do with results and can sometimes infer whose tenure was dependent on this thing getting published. I will also refrain from commenting on publishing papers by psychologists, other than to say that they can get away with publishing an awful lot of “questionnaire” based and “pencil and paper” studies.  Medical doctor psychiatrists always seem to have to sample at least one bodily fluid to get something published.

The author of the study — Justin Lavner of UCLA — basically says that people who have “cold feet” or “jitters” at the time of the wedding are more likely to divorce later. 
The study followed 464 newlyweds.  He says nobody can say for sure whether folks had doubts about their partner or about the institution of marriage in general.  This tells me the study could have been designed to answer this question in more detail.  But as it is, we do know that 47% of husbands and 38% of wives had doubts. 
After four years, 19% of women who had doubts were divorced, as opposed to 8% who did not.  For men, 14% who had doubts were divorced four years later, versus 9% of those who did not.  Of the 36% of those couples of which neither partner had doubts, 6% still got divorced. I basically like psychologists.  Like most psychiatrists, I have learned to live in a symbiosis with them, where they do the psychotherapy and the psychiatrists do the pill-pushing.  Notice, I am talking mostly about PhD psychologists and clinicians. 
I’ve worked with patients who have been seen by professionals with lesser degrees.  A few actually get well.  At any level, most are subject to professionals who try to provide the minimal necessary to charge some sort of insurance.  They are the devotees of the ‘easy hour,” people who do things like light candles and tell patients to spend an hour “relaxing” from their stress.
Read more on Cold Feet Might Mean No-Go for the Future of Marriage…

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By every measure, America is hanging onto its first world status by a thread.  And even that is arguable.  We have been in slow decline toward third world status for the last 30 years.  And nothing speaks to this reality more than this country’s poverty rates. It is sad that poverty is measured in percentages and indices that are debatable at best.  As in many news stories, an effort is made to personalize — to render concrete — these elusive numbers.  The happiness of the person who found free fruit but could not afford it at Walmart, cited at the end of the article, is a touching story. These are the stories of real poor folks, who have seen me as patients, in rural northern California. Folks like the married couple, both of whom were on active army duty in both Iraq and Afghanistan.  They left their kids with their parents while they served.  They wanted to continue serving, but were informed they could not because of “military cutbacks.”  They asked for job direction from VA counselors who were no help, and finally both found minimum wage jobs.  Their new wages combined total less than 1/4 of their military salaries, but they still make too much to qualify for insurance.  They own some land — from the family – where they are living with their children in their parents’ houses.  They are wondering how they are going to pay for their children’s medical care. Like the young man who has impacted wisdom teeth and back pain from a serious accident at a saw mill.  Something ran amok and tons of wood fell on his back. He cannot pay for either dental care or an operation on his back.  His family has chipped in for medical marijuana.  He has no idea of how to do anything except stay home, in pain, depressed, and stoned. Or there’s the older woman on oxygen who cannot lift her tank and has a bag of pills she cannot lift either.  She needs me to hold her hand while she limps with great pain into my office.  She has a broken hip but until she is old enough for Medicare — a year or so — mostly her friends shop for her and bring her everything she needs.  What she really needs is an operation on her hip but has no idea how to pay for it.  I tell her to ask her doctor for some kind of a device to assist ambulation.  She says a cane is not enough and nobody will pay for a walker; certainly not for a wheelchair. Some people think Obamacare might help but have no idea what to do until then.  I have seen unemployed young people who are glad they are still on their parents’ health insurance. The kinds of things I am seeing are the kind of things that missionaries see in third world counties.  I know some physicians who have been discouraged from that kind of work, simply because people need basic food and shelter before they can be cured or managed.  From what the people above tell me, they do not seem to have these things, either. Hanging on by a thread to our first world status?  No.  The thread has broken and we are third world. Now.

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In the National World War II museum, it is easy and even triumphant and pride-generating to look back and see some of the scientific advances made during World War II.  There’s no doubt that science is advancing.  But I wonder if our ethics can keep pace.

I am fairly proud of Teflon.  And synthetic cortisone is widely used and may have saved plenty of lives. It’s a steroid that knocks down the action of the immune system.  When a medical substance becomes cheaper and easier to use and known to the public, then it runs a real danger of getting overused.  Most concern about overuse is focused on illegal steroids taken by athletes.  Nevertheless, everything that can be helpful and fast may make things worse. One example would be the over-prescribing of steroids to kids with allergies.

Penicillin had been invented before WWII, but its use did not become widespread until WWII.  Of course, it took people awhile to find out about the ability of bacteria to develop resistances to antibiotics.  This has led to newer and stronger antibiotics, which would not be the worst thing in the world. Unfortunately, the excessive use of antibiotics has led to untreatable infections, such as methicilline-resistant strep and an untreatable strain of tuberculosis. Read more on Science and War (and Ethics)…

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I am happy — really happy — with something the state of California has done.  It is a very, very good thing.  They have become the first state in the nation to ban therapy that tries to turn gay teens straight. I am armed with subjective histories.  My heart, if not my brain, goes to them first. My first private office in California was in San Diego and just happened to be near the center of the alternative lifestyle community of that fine burg.  I heard tear-stained stories from gay guys whose parents had “suggested” therapy of this sort.  One man, who saw me for treatment of a physical pain syndrome, told me how his parents wanted and believed in a heterosexual son.  He cried as he told me about their “Christianity” and their desire for him to father a family.  They would even try to encourage him on dates with girls when he felt “less than nothing.”  Curiously enough, I remember him as being part of one of the most highly committed and long lasting dyadic relationships I have ever known.  He had a loving male partner who brought him to every appointment and waited in the waiting room. When I approach a situation, I do not start with subjective data, however emotional.  I look farther.

I know that the searchers of the human genome for markers for homosexuality have come up empty.  This seems to mean that homosexuality is probably not genetic.  It does not mean it is not biological.  Last time I tuned in, people seemed to believe that homosexuality — at least in males — seemed related to stress during pregnancy.  I was still back in Europe when I read that the largest number of gay males ever born in a similar set of circumstances were the male children born to women who had been incarcerated in concentration camps. Read more on Good for California! “Straightening Out” Gays Is Now Illegal…

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